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柴学军
柴学军(Chai,Xuejun),女,1968年7月出生于新疆库尔勒,德籍华人,德国医学博士。1990年7月新疆医科大学本科毕业获医学学士学位,1990.7至1999.4在新疆矿务局总医院妇产科工作,先后任住院医师和主治医师,2000.2-2003.4在德国弗莱堡大学附属医院内科做访问学者,主要从事乙型肝炎的基因治疗研究。并于2016年获得具有130年历史的德国杰出医学人才奖-马提尼奖(Martini Price),2018年6月以高层次人才引进西安医学院

   柴学军(Chai,Xuejun,女,19687月出生于新疆库尔勒,德籍华人,德国医学博士。19907月新疆医科大学本科毕业获医学学士学位。20年来主要利用荧光免疫组织化学,激光共聚焦显微镜,子宫内点击转染,器官型脑片培养,活体动态观察显微镜,钙离子成像,电镜等先进的形态学技术和原位杂交,质粒构建,Western blot和实时荧光定量PCR等先进的分子生物学技术对大脑发育特别是神经元迁移,成体神经干细胞和学习记忆原理等神经生物学热点问题进行了深入细致的研究,先后发表在Nature子刊等国际知名学术期刊上发表SCI论文26篇,其中第一作者7篇(4篇为中科院一区),作为主要人员先后参与多个德国和欧共体科研项目,多次应邀参加欧洲,美国和德国神经科学和解剖学会议并作口头报告或墙报展示,并于2016年获得具有130年历史的德国杰出医学人才奖-马提尼奖(Martini Price)。20186月进入西安医学院分配在基础部解剖教研室工作。


     主要经历:

1990.71999.4在新疆矿务局总医院妇产科工作,先后任住院医师和主治医师

2000.2-2003.4在德国弗莱堡大学附属医院内科做访问学者,主要从事乙型肝炎的基因治疗研究。

2003.5获德国国家神经科学研究生院奖学金在德国弗莱堡大学医学院攻博。

2007.03获得医学博士学位,毕业后在弗莱堡大学医学院做博士后研究。

2010.3-2012.9在弗莱堡大学医学院解剖研究所做课题负责人。

2012.10-2018.06任职汉堡大学医学院分子神经科学中心研究员。

      

 发表文章: (IF: 影响因子)
1. Ciqing Yang, Xiaoying Li, Shuanqing Li, Xuejun chai, Lihomh Guan, Liang Qiao, Juntang Lin. Organotypic Slice Culture Based on In Ovo Electroporation for Chicken Embryonic Central Nervous System.
J. Cell. Mol.Med. 2018; 1-14. 

2. Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, Failla AV, Zobiak B, Sibbe M, Westbrook GL, Lutz D, Frotscher M. Trajectory analysis unveils Reelin's role in the directed migration of granule cells in the dentate gyrus. J Neurosci. 2017 Nov 14.IF=5.924) 

3Frotscher M, Zhao S, Wang S, Chai X. Reelin Signaling Inactivates Cofilin to Stabilize the Cytoskeleton of Migrating Cortical Neurons. Front Cell Neurosci. 2017 May 23;11:148. IF=4.555
4
Xie J, Li X, Zhang W, Chai X, Huang Y, Li K, Cheng X, Zhao S. Aberrant expression of LIMK1 impairs neuronal migration during neocortex development. Histochem Cell Biol. 2017; 147(4):471-479. 2.78. IF=2.780
5
.  Chai X, Zhao S, Fan L, Zhang W, Lu X, Shao H, Wang S, Song L, Failla AV, Zobiak B, Mannherz H G, Frotscher M. Reelin and cofilin cooperate during the migration ofcortical neurons: A quantitative morphological analysis. Development. 2016; 143(6):1029-40.IF=6.059
6. Chai X& Frotscher M. How does Reelin signallingregulate the neuronal cytoskeleton during migration? Neurogenesis. 2016
:3:1. 

7. Chai X, Fan L, Shao H, Lu X, Zhang W, Li J, Wang J, Chen S, Frotscher M, Zhao S. Reelin induces branching of neurons and radial glial cells during corticogenesis. Cerebral Cortex. 2015; 25:36403653. IF=8.285
8. 
Wang J, Song L, Li L, Zhang W, Chai X, An L, Chen S, Frotscher M, Zhao S. Src controls neuronal migration by regulating the activity of FAK and cofilin. Neuroscience. 2015; 292:90-100.IF=3.231

9. Chai X, Münzner G, Zhao S, Tinnes S, Kowalski J, H?ussler U, Young C, Haas CA, Frotscher M. Epilepsy-Induced Motility of Differentiated Neurons. Cerebral Cortex. 2014; 24(8):2130-40. IF=8.285
10. Frotscher M, Studer D, Graber W, Chai X, Nestel S, Zhao S. Fine structure of synapses on dendritic spines. Frontiers in Neuroanatomy. 2014; 8:94. 
IF=3.260
11. Studer D, Zhao S, Chai X, Jonas P, Graber W, Nestel S,Frotscher M. Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. Nature Protocols. 2014; 9(6):1480-95. 
IF=9.646

12. Li L, Zhang W,Chai X, Zhang Q, Xie J, Chen S, Zhao S. Neuronal maturation and laminar formation in the chicken optic tectum are accompanied by the transition of phosphorylated cofilin from cytoplasm to nucleus. Gene Expr Patterns. 2014;    16(2):75-85.IF=1.485

13. Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, SaetzlerK, Frotscher M. Structural plasticity of spines at giant mossy fiber synapses. Frontiers in Neural Circuits. 2012; 6:103. IF=3.879
14. Zhao S, Studer D, Chai X, Graber W, Brose N, Nestel S, Young C, Rodriguez EP, SaetzlerK, Frotscher M. Structural plasticity of hippocampal mossy fiber synapses as revealed by high-pressure freezing. J Comp Neurol. 2012; 520(11):2340-51. 
IF=3.331
15. Long H, Bock HH, Lei T, Chai X, Yuan J, Herz J, Frotscher M, YangZ. Identification of alternatively spliced Dab1 and Fyn isoforms in pig. BMC Neuroscience. 2011; 12:17. 
IF=2.304
16. Kr
üger MT, Zhao S, Chai X, Brunne B, BouchéE, Bock HH, Frotscher M. Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column. Eur J Neurosci. 2010; 32(10):1611-7. IF=2.975

17. Forster E, Bock HH, Herz J, Chai X, Frotscher M, Zhao S. Emerging Topics in Reelin Function. Eur J Neurosci. 2010; 31(9): 15111518. IF=2.975
18. Chai X, Forster E, Zhao S, Bock HH, Frotscher M. Reelin stabilizes the actincytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci. 2009; 29:288-299.
IF=5.924
20. Chai X, Forster E, Zhao S,Bock HH, Frotscher M. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Communicative & Integrative Biology. 2009; 2:4, 375-377. 
21. Zhao S, Chai X, Frotscher M. Balance between neurogenesis and gliogenesisin the adult hippocampus: role for reelin. Dev Neurosci. 2007;29(1-2):84-90. 
IF=2.898
22. Zhao S*, Chai X*, Bock HH, Brunne B, Forster E, Frotscher M. Rescue of the reeler phenotype in the dentate gyrus by wild-type coculture is mediated bylipoprotein receptors for Reelin and Disabled 1. J Comp Neurol. 2006; 495(1):1-9. (*equal contribution) 
IF=3.331

23. Forster E, Jossin Y, Zhao S, Chai X, Frotscher M,Goffinet AM. Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. Eur J Neurosci. 2006; 23(4):901-9. IF=2.875
24. Zhao S, Chai X, Frotscher M. Reelin is a positional signal for thelamination of dentate granule cells. Development . 2004; 131(20):5117-25. IF=6.059

25. Zhao S, Forster E, Chai X, Frotscher M. Different signals control laminar4specificity of commissural and entorhinal fibers to the dentate gyrus. J Neurosci. 2003; 23(19):7351-7. IF=5.924
26. 
李玲玲,张伟,杜蕊,宋玲珍,柴学军,胡新德,陈树林,赵善廷。小鼠cofilin-1基因及其真核表达载体的构建与体内外表达。西北农林科技大学学报,2014; 42(09): 01-10. 
27
. 胡新德,张伟,刘笙腩,李玲玲,宋玲珍,柴学军,陈树林,赵善廷小鼠海马发育过程中丝切蛋白及其磷酸化调节基因表达差异分析动物医学进展。2013; 34(7):6-11.

在研项目高层次引进人才项目"Reelin 在神经元迁移中的作用及分子和细胞机制研究",启动资金100万。

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