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苟兴春-基础医学部副处级调研员
苟兴春,医学博士,教授,硕士研究生导师。任基础医学部副主任、基础医学实验教学中心副主任。中国细胞生物学学会第十届理事、陕西省细胞生物学学会常务理事、陕西省抗癌协会肿瘤标志委员会委员、国家自然科学基金评审专家、国家国际科技合作专项专家库成员、陕西省青年科技工作者协会第四届委员会会员、多家SCI杂志及中文核心期刊审稿人。 主要研究方向为:神经再生与脑保护机理及转化医学的研究。


苟兴春,男,19733月出生,医学博士,博士后、教授、耶鲁大学访问学者。第四军医大学硕士研究生导师。陕西省中青年科技创新领军人才、国家创新创业优秀导师、西安医学院领军人才。现任西安医学院基础医学部副主任、基础与转化医学研究所所长。

 

任:

中国细胞生物学学会第十届理事、

陕西省细胞生物学学会常务理事、

中国药理学会麻醉分会委员、

陕西省肿瘤标志委员会委员、

转化医学电子杂志编委

Cancer Translational Medicine编委会成员

  

  生物学学士、神经生物学硕士、细胞生物学博士、麻醉学博士后、耶鲁大学神经外科访问学者。专长于神经再生与脑保护、阿尔茨海默病的机制与防治。2010年被Cancer Science授予“青年科学家奖”(Young Scientist Award)。

 

教育、工作经历:

1992-1996年,兰州大学生命科学学院;

1996-2003年,西安迪赛生物药业,工程师 

2003年就读第四军医大学神经生物学硕士研究生,在导师鞠躬院士指导下,从事中枢神经再生的研究,

20067月获硕士学位;20069月就读第四军医大学细胞生物学专业,攻读博士学位,导师为陈志南院士,从事自噬与肿瘤的相关研究。

2009-至今,在西安医学院细胞生物学教研室任教与科研;

2011-2013年,第四军医大学麻醉学专业博士后;

2013.12-2014.12,耶鲁大学神经外科访问学者。

 

科研项目:

 主要研究方向:为神经再生与修复、老年痴呆机制及防治。现主持国家自然科学基金面上项目3项(其中已结题2项),省教育厅和卫生厅科研计划各1项,人社厅留学基金1项,陕西省重点项目1项,总科研经费近200万元。是西安医学院第一个国家自然科学基金获得者。

 

国家自然科学基金主持项目(3项)

1、2014年国家自然科学基金面上项目,70万。(81471415 "Aβ-PirB-Tau"通路调控突触可塑性:阿尔茨海默症发生的分子机制及防治策略探讨。

2、2010年国家自然科学基金面上项目,30万。(81071060PirB重链VHH抗体的筛选及其治疗脑缺血损伤的研究。

3、2012年国家自然科学基金面上项目,70万。(81271290)靶向运载Ngn2诱导星形胶质细胞转分化为神经元:促进缺血性脑损伤后神经功能恢复的新策略。 

 

论文发表:

已发表论文60余篇,SCI收录32(其中第一或通讯作者25篇,IF>20的论文1篇,IF>10的论文1篇,IF>5的论文8篇,影响因子总计超过130分)。

SCI论文清单见:

1.     Yu, X.,X. Gou(共一), P. Wu, L. Han, D. Tian, F. Du, Z. Chen, F. Liu, G. Deng, A.T. Chen, C. Ma, J. Liu, S.M. Hashmi, X. Guo, X. Wang, H. Zhao, X. Liu, X. Zhu, K. Sheth, Q. Chen, L. Fan, and J. Zhou, Activatable Protein Nanoparticles for Targeted Delivery of Therapeutic Peptides. Adv Mater, 2018. 30(7).

2.     Wang, X., X. Liu, Y. Ren, Y. Liu, S. Han, J. Zhao, X. Gou(通讯), and Y. He, PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression. Mol Med Rep, 2018.

3.     Lao, K., N. Ji, X. Zhang, W. Qiao, Z. Tang, and X. Gou(通讯), Drug Development for Alzheimer's Disease: Review. J Drug Target, 2018: p. 1-29.

4.     Guo, X., G. Deng, J. Liu, P. Zou, F. Du, F. Liu, A.T. Chen, R. Hu, M. Li, S. Zhang, Z. Tang, L. Han, J. Liu, K.N. Sheth, Q. Chen, X. Gou(通讯), and J. Zhou, Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy. ACS Nano, 2018. 12(8): p. 8723-8732.

5.     Guo, H., L. Xun, R. Zhang, and X. Gou(通讯), Ratio of CD147(high)/CD147(low) in CD4(+)CD25(+) T cells: A potential biomarker for early diagnosis and prediction of response to therapy for autoimmune diseases. Med Hypotheses, 2018. 115: p. 1-4.

6.     Gao, X., Y. Mi, N. Guo, H. Xu, P. Jiang, R. Zhang, L. Xu, and X. Gou(通讯), Glioma in Schizophrenia: Is the Risk Higher or Lower? Front Cell Neurosci, 2018. 12: p. 289.

7.     Deng, B., L. Li, X. Gou(共一), H. Xu, Z. Zhao, Q. Wang, and L. Xu, TAT-PEP Enhanced Neurobehavioral Functional Recovery by Facilitating Axonal Regeneration and Corticospinal Tract Projection After Stroke. Mol Neurobiol, 2018. 55(1): p. 652-667.

8.     Zhao, Z.H., B. Deng, H. Xu, J.F. Zhang, Y.J. Mi, X.Z. Meng, X.C. Gou(通讯), and L.X. Xu, PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury. Cell Mol Neurobiol, 2017. 37(4): p. 707-715.

9.     Zhao, W., H. Qian, R. Zhang, X. Gao, and X. Gou(通讯), MicroRNA targeting microtubule cross-linked protein (MACF1) would suppress the invasion and metastasis of malignant tumor. Med Hypotheses, 2017. 104: p. 25-29.

10.   Mi, Y.J., H. Chen, N. Guo, M.Y. Sun, Z.H. Zhao, X.C. Gao, X.L. Wang, R.S. Zhang, J.B. Zhou, and X.C. Gou(通讯), Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior. Front Aging Neurosci, 2017. 9: p. 199.

11.   Gao, X., Y. Mi, N. Guo, H. Xu, L. Xu, X. Gou(通讯), and W. Jin, Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy. Front Immunol, 2017. 8: p. 774.

12.   Dang, Y., T. Liu, X. Mei, X. Meng, X. Gou, B. Deng, H. Xu, and L. Xu, Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury. J Surg Res, 2017. 220: p. 363-371.

13.   Han, L., Q. Cai, D. Tian, D.K. Kong, X. Gou, Z. Chen, S.M. Strittmatter, Z. Wang, K.N. Sheth, and J. Zhou, Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles. Nanomedicine, 2016. 12(7): p. 1833-1842.

14.   Gou, X., X. Tang, D.K. Kong, X. He, X. Gao, N. Guo, Z. Hu, Z. Zhao, and Y. Chen, CD147 is increased in HCC cells under starvation and reduces cell death through upregulating p-mTOR in vitro. Apoptosis, 2016. 21(1): p. 110-9.

15.   Gao, X., Y. Mi, N. Guo, Z. Hu, F. Hu, D. Liu, L. Gao, X. Gou(通讯), and W. Jin, Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics. Oncotarget, 2016. 7(52): p. 85963-85974.

16.   Zhao, Y., B. Deng, Y. Li, L. Zhou, L. Yang,X. Gou, Q. Wang, G. Chen, H. Xu, and L. Xu, Electroacupuncture Pretreatment Attenuates Cerebral Ischemic Injury via Notch Pathway-Mediated Up-Regulation of Hypoxia Inducible Factor-1alpha in Rats. Cell Mol Neurobiol, 2015. 35(8): p. 1093-103.

17.   Wang, Q., Y. Sun, Y. Ren, Y. Gao, L. Tian, Y. Liu, Y. Pu, X. Gou, Y. Chen, and Y. Lu, Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Neural Plast, 2015. 2015: p. 249756.

18.   Gou, X.C., D. Kong, and X. Tang, Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy. Asian Pac J Cancer Prev, 2015. 16(13): p. 5143-7.

19.   Gao, X., Y. Mi, A. Yan, B. Sha, N. Guo, Z. Hu, N. Zhang, F. Jiang, and X. Gou, The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis. Asia Pac J Clin Oncol, 2015. 11(4): p. e13-21.

20.   Chen, Y.,X. Gou, D.K. Kong, X. Wang, J. Wang, Z. Chen, C. Huang, and J. Zhou, EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Oncotarget, 2015. 6(32): p. 32575-85.

21.   Sha, B., W. Gao, S. Wang, X. Gou, W. Li, X. Liang, Z. Qu, F. Xu, and T.J. Lu, Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats. J Appl Toxicol, 2014. 34(4): p. 345-56.

22.   Guo, N., A. Yan, X. Gao, Y. Chen, X. He, Z. Hu, M. Mi, X. Tang, and X. Gou(通讯), Berberine sensitizes rapamycinmediated human hepatoma cell death in vitro. Mol Med Rep, 2014. 10(6): p. 3132-8.

23.   Guo, F., W.L. Jin, L.Y. Li, W.Y. Song, H.W. Wang,X.C. Gou, Y.J. Mi, Q. Wang, and L. Xiong, M9, a novel region of amino-Nogo-A, attenuates cerebral ischemic injury by inhibiting NADPH oxidase-derived superoxide production in mice. CNS Neurosci Ther, 2013. 19(5): p. 319-28.

24.   Gou, X., Q. Zhang, N. Xu, B. Deng, H. Wang, L. Xu, and Q. Wang, Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia. Brain Inj, 2013. 27(11): p. 1311-5.

25.   Deng, B.,X. Gou(共一), H. Chen, L. Li, H. Zhong, H. Xu, F. Jiang, Z. Zhao, Q. Wang, and L. Xu, Targeted delivery of neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury. Biomaterials, 2013. 34(34): p. 8786-97.

26.   Wang, Q., F. Wang, X. Li, Q. Yang, X. Li, N. Xu, Y. Huang, Q. Zhang, X. Gou, S. Chen, and L. Xiong, Electroacupuncture pretreatment attenuates cerebral ischemic injury through alpha7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats. J Neuroinflammation, 2012. 9: p. 24.

27.   Chen, Y., X. Gou, X. Ke, H. Cui, and Z. Chen, Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I. PLoS One, 2012. 7(7): p. e40965.

28.   Hou, Q., X. Tang, H. Liu, J. Tang, Y. Yang, X. Jing, Q. Xiao, W. Wang, X. Gou, and Z. Wang, Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci, 2011. 102(7): p. 1287-92.

29.   Gou, X., Q. Wang, Q. Yang, L. Xu, and L. Xiong, TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke. J Drug Target, 2011. 19(2): p. 86-95.

30.   Wang, Q., Y. Peng, S. Chen, X. Gou, B. Hu, J. Du, Y. Lu, and L. Xiong, Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. Stroke, 2009. 40(6): p. 2157-64.

31.   Wang, Q.,X. Gou(共一), W. Jin, L. Xiong, L. Hou, S. Chen, H. Zhang, X. Zhu, and L. Xu, TAT-mediated protein transduction of Nogo extracellular peptide 1-40 and its biological activity. Cell Mol Neurobiol, 2009. 29(1): p. 97-108.

32.   Wang, Q., Q. Ding, Y. Zhou, X. Gou, L. Hou, S. Chen, Z. Zhu, and L. Xiong, Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology, 2009. 110(6): p. 1279-86.

33.   Gou, X., Q. Ru, H. Zhang, Y. Chen, L. Li, H. Yang, J. Xing, and Z. Chen, HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation. Cancer Sci, 2009. 100(5): p. 837-43.

34.   Chen, Y., H. Zhang, X. Gou, Y. Horikawa, J. Xing, and Z. Chen, Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis. Cancer Lett, 2009. 278(1): p. 113-21.

35.   Wang, Q.,X. Gou(共一), L. Xiong, W. Jin, S. Chen, L. Hou, and L. Xu, Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis. Anesthesiology, 2008. 108(6): p. 1071-80.

 

获奖:

1.苟兴春,Young Scientist Award(青年科学家奖),Cancer Science(癌症科学杂志),2010

2.苟兴春,第六届亚太肿瘤学术会议论文二等奖,2008

3.第一届天士力奖教金获得者

4.连续3年获西安医学院优秀教师

5.培养的硕士研究生获2014年度国家奖学金


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